These symptoms commonly occur in large muscles in the legs, chest, upper arms, shoulders, or lower back, but can occur elsewhere. The muscle pain statin drugs cause is directly related to the way statin drugs work. Most often when statins are responsible for the muscle pain, one of three things happen. Statins can cause unpleasant muscle sensations, such as stiffness and tenderness My legs have recently become very painful and hurt from my knees up to my buttocks. If you have muscle weakness with or without pain… At last, scientists have discovered the reason statin drugs used to treat high cholesterol often cause muscle pain or weakness. According to research recently published in the Journal of the American College of Cardiology, this class of drugs affects the skeletal muscles, but not the heart muscle. Statin-related muscle … These symptoms commonly occur in large muscles in the legs, chest, upper arms, shoulders, or lower back, but can occur elsewhere. Although statins are lipid-lowering drugs that block cholesterol biosynthesis, but also exert immunomodulatory, anti … The clearest risk from statins is muscle damage resulting in weakness, tenderness, or pain. Statin-related muscle … You develop: –muscle pain all over without weakness –weakness of the large muscles in the upper arms and thighs without pain, or –both muscular pain and weakness. The clearest risk from statins is muscle damage resulting in weakness, tenderness, or pain.